G-quadruplex DNA is the target of several natural and synthetic small molecules with antiproliferative and antiviral activity.We here report the synthesis through Sonogashira reaction and A3 coupling of a Square Acrylic Plaque disubstituted anthracene derivative, 9,10-bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop-2-yne-1-yl]anthracene.The binding of
The APOBEC3 gene cluster encodes six cytidine deaminases (A3A-C, A3DE, A3F-H) with single stranded DNA (ssDNA) substrate specificity.For the moment A3A is the only enzyme that can initiate catabolism of both mitochondrial and nuclear DNA.Human A3A expression is initiated from two different methionine codons M1 or M13, both of which are in adequate
Grasslands are the main land cover type and one of the most important ecosystems in arid and alpine endorheic basins.The vegetation coverage of grasslands is spatially heterogeneous in arid and alpine areas and it may lead to variations in water allocation.The Soil and Water Assessment Tool (SWAT) is one of the most widely used semi-distributed cat
Penurunan fungsi kognitif merupakan masalah serius pada lansia yang akan mengakibatkan lansia sulit untuk hidup mandiri dan meningkatkan risiko terjadinya demensia sehingga lansia mengalami gangguan perilaku dan penurunan kualitas hidup.Gangguan fungsi kognitig ini apabila terjadi dalam jangka waktu yang Panjang dan tidak segera dilakukan penangana
The microtubule (MT) plus-end motor kinesin heavy chain (Khc) is well known for its role in long distance cargo transport.Recent evidence showed that Khc is also required for the organization of the cellular MT network by mediating MT sliding.We found that mutations in Khc and the gene of its adaptor protein, kinesin light chain (Klc) resulted in i